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KMID : 1001020120100010027
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Korean Journal of Urological Oncology
2012 Volume.10 No. 1 p.27 ~ p.33
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Variants in Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) Gene are Associated with Susceptibility to Prostate Cancer
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Kim Hae-Jong
Lee Jae-Hyouk
Han Jun-Hyun
Lee Ji-Youl
Chang In-Ho
Kim Tae-Hyoung
Kim Kyung-Do
Myung Soon-Chul
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Abstract
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Purpose: Recently, Toll-like receptors (TLR) genes are associated with prostate cancer risk. Interleukin-1 receptor-associated kinase 4 (IRAK4) is a critical component in the TLR signaling pathway. In this study, sequence variants in the IRAK4 gene were investigated to determine whether they were associated with prostate cancer risk in a Korean cohort.
Materials and Methods : An association study between 19 single nucleotide polymorphisms (SNPs) of the IRAK4 gene and prostate cancer was performed in 463 Korean male subjects including 240 prostate cancer patients and 223 healthy controls. SNPs were genotyped and their association with the risk of prostate cancer was evaluated using logistic regression analysis.
Results: The statistical analysis revealed that one SNP (rs4238087) showed significant association with the risk of prostate cancer (p=0.05, OR=0.65). One common SNP (rs4251473) showed significant association with the aggressiveness of prostate cancer (p=0.02, OR=0.09).
Conclusions: The findings of this study suggest that polymorphisms of the IRAK4 gene might be associated with the risk for prostate cancer in Korean men.
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KEYWORD
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Interleukin-1 receptor-associated kinase 4 (IRAK4), Prostate cancer, Single nucleotide polymorphism, Susceptibility
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